Premarin is a mixture of horse estrogens applied in the treatment of several conditions, such as hormone deficiency treatment in younger women, menopause symptoms management, certain cancer types symptoms reduction and osteoporosis prevention. Pills are taken once daily either continuously or cyclically, as appropriate. In order to reduce the risk of uterus cancer, the drug is often co-administered with progesterone.
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What is Premarin?
The active ingredients of Premarin are a combination of estrogens, namely estrone and equilin. The content of various estrogens in the drug represents the blend of hormones obtained from pregnant mares' urine, hence the name of the drug. The medication is used in estrogen therapy aimed to treat various symptoms and conditions of women after the menopause, as well as some forms of breast and prostate cancer.
What are the indications for using Premarin?
These are the conditions which may call for Premarin treatment:
- Menopause-related symptoms
Lack of estrogen naturally produced by the body during this period of woman’s life may lead to vasomotor symptoms like hot flashes, palpitations, vaginal dryness, as well as feelings of fatigue, anxiety, and increased irritability.
- Postmenopausal osteoporosis
Insufficient levels of estrogen in the woman’s body can also lead to osteoporosis, a condition when the bones become much more brittle and prone to fracturing. In many cases Premarin estrogen therapy is a preferred way of preventing the decrease of the bone mass.
- Hypoestrogenism in women
Due to various reasons, the woman’s body may not produce enough estrogens for normal functioning. In these cases Premarin therapy is used to supply the organism with the necessary amounts of hormones.
- Breast cancer and prostate carcinoma
Premarin is also utilized to palliate the symptoms of metastatic breast cancer in men and women alike, as well as the prostate carcinoma symptoms in men.
What is the dosage of Premarin?
For menopause symptoms treatment, 0.3 mg Premarin per day is a starting dose that may be adjusted individually based on the drug’s effect. The drug can be taken continuously or administered cyclically. Breast cancer patients take 10 mg of Premarin three times per day during a three month course. For prostate carcinoma treatment, the dose of the drug is 1.25 mg thrice a day, which may be increased on a personal basis.
What are the contraindications for using Premarin?
Premarin should not be used by patients with breast cancer except for metastatic form, by pregnant women, by patients with menstrual cycle disorders, and by patients with liver disease.
What are the adverse effects of Premarin?
Among the side effects of Premarin use are unexpected vaginal bleeding, abdominal pain, leg cramps, fatigue, and breast tenderness.