Aygestin is an oral hormonal contraceptive containing norethindrone 5 mg. It is also prescribed for menstrual disorders, amenorrhea, endometriosis and vaginal bleeding due to hormone disruption. The agent stops the growth of uterus linen signaling hormone changes to restore menstruation and making it harder to conceive.
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What is Aygestin?
Aygestin is a synthetic, orally active progestin. It comes in 5 mg tablets with Norethindrone acetate as main ingredient, which works by altering the lining of the uterus and stopping gonadotropin production, thus leading to ovulation prevention in females. The drug is also used to treat abnormal uterine bleeding and related conditions, including amenorrhea and endometriosis. It is widely applied for uterine hemorrhage prevention in pre-surgical and complicated non-surgical gynecological cases.
When is Aygestin prescribed?
Aygestin is prescribed to women with endometriosis, secondary amenorrhea and abnormal uterine bleeding caused by hormonal imbalance if there is no organic pathology, such as uterine cancer or submucosal fibroids. The drug is also prescribed alone to treat premenstrual syndrome, irregular or painful periods and in combination with estrogen to treat menopausal syndrome. The low-dose drug is also used to prevent pregnancy in women of childbearing potential.
How to take Aygestin?
Aygestin therapy should be adapted to specific indications of each patient. The average dose for abnormal uterine bleeding and secondary amenorrhea is 2,5-10 mg a day for 5-10 days administered during the second half of the menstrual cycle. The average dose for endometriosis is 5 mg a day for 2 weeks with subsequent dose-escalation scheme by 2,5 mg a per day every two weeks until the maximum daily dose of 15 mg a day is reached. The duration of treatment may constitute from 6 to 9 months.
What are Aygestin side-effects?
Aygestin may cause spotting, breakthrough bleeding, irregular menstrual cycle, edema, nausea, headache, mood swings, insomnia, urticaria, breast tenderness and weight changes. Report to your prescribing physician if these side-effects persist or worsen. Discontinue using the drug and seek immediate medical attention if you develop the signs of thrombophlebitis or pulmonary embolism.
When is Aygestin contraindicated?
Aygestin is contraindicated to pregnant women, to women with liver problems, undiagnosed vaginal bleeding, breast carcinoma, thrombophlebitis, thromboembolitic disorders and cerebral apoplexy. Care should be exercised when administering the drug to women with underlying risk for thrombotic disorders, including thrombophilia, heart disease, obesity and prolonged immobilization.